This page summrizes work being done on allowing users to submit large bitstreams into DSpace (via HTTP).
As of DSpace 1.8, there us a 2GB limit for file upload in Cocoon, the framework used for the XMLUI. This limit can be increased using the following property:
via Globus
This project is realized at University of Exeter:
http://or2013.net/content/moving-big-data-dspace (OR 2013 talk)